Francesco A. Aprile

This paper introduces a molecular rotor-based platform to distinguish dynamic protein condensates from toxic aggregates using fluorescence lifetime imaging, demonstrating its application with α-synuclein in Parkinson's disease.

The paper tracks mitochondrial gene expression in live neurons using nanotweezers and finds downregulation of MT-ND1 and MT-ATP6 after exposure to α-synuclein aggregates.

This study engineers a dimeric single-domain antibody that improves detection and neutralization of amyloid-β oligomers, showing enhanced specificity and efficacy compared to its monomeric form.

This study investigates how N-terminal truncation and surface wetting influence α-synuclein condensate maturation and suggests a mechanism linking surface interactions to toxic aggregate formation.

This paper introduces a combined SICM-OPM system for simultaneous non-contact topographical and volumetric fluorescence imaging in live cells, demonstrating its use in studying cellular remodeling and molecular delivery.

This study uses molecular rotors to detect and compare oligomer formation and conversion to amyloids in wild-type and two α-synuclein variants, revealing differences in aggregation kinetics.

The paper identifies MOAG-4/SERF as modifiers of amyloid formation through charge complementation, showing that charge interactions drive protein aggregation and toxicity.

The paper examines soluble Aβ aggregates in CSF from AD, MCI, and healthy controls, finding stage-specific differences in aggregate size and toxicity mechanisms.