Arap1 Loss Causes RPE Phagocytic Dysfunction and Subsequent Photoreceptor Death
Andy Shao, Antonio Jacobo Lopez, JiaJia Chen, Addy Tham, Seanne Javier, Alejandra Quiroz Alonso, Sonia Frick, Edward M. Levine, K. C. Kent Lloyd, Brian C. Leonard, Christopher John Murphy, Thomas M. Glaser, Ala Moshiri
This study shows that Arap1 in retinal pigment epithelium (RPE) is essential for photoreceptor survival through its role in phagocytosis, as Arap1 deficiency leads to photoreceptor degeneration.
bioRxiv · Aug 9, 2021 · PreprintMolecular Biology