Ala Moshiri

A Translational Reference for Green Autofluorescence Imaging in the Rhesus Macaque Eye using the OcuMet Beacon

This study establishes normative green autofluorescence (GAF) values in rhesus macaques across different retinal regions and links GAF to age, intraocular pressure, and retinal structure.

Ocular Safety and Efficacy of AAV-mediated Tyrosinase Gene Augmentation in a Nonhuman Primate Model

This study evaluates the safety and efficacy of AAV-mediated TYR gene augmentation in nonhuman primates for OCA1 treatment, showing localized hypermelanosis and RPE transduction without severe adverse effects.

Genome-wide association and multi-omics functional screens reveal the genetic architecture of foveal development

This paper identifies genetic variants and genes associated with foveal hypoplasia using GWAS and multi-omics data, and establishes a zebrafish model to study the condition.

Super-resolution microscopy reveals a Rab6a-dependent trafficking hub for rhodopsin at the mammalian rod photoreceptor Golgi

This study uses super-resolution microscopy to show that Rab6a regulates rhodopsin trafficking from the trans-Golgi in mammalian rod photoreceptors, with implications for retinal health.

Genome-Wide Insights into the Genes and Pathways Shaping Human Foveal Development

This study identifies 123 genome-wide significant loci associated with foveal pit depth, revealing new biological pathways and genes involved in human foveal development.

Stimulating the regenerative capacity of the human retina with proneural transcription factors in 3D cultures

This study shows human Muller glia can generate new neurons in adults using proneural transcription factors in 3D cultures.

Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques

This paper establishes a rhesus macaque model of glaucomatous neurodegeneration using silicone oil injection, showing RGC death, optic nerve degeneration, and functional deficits similar to human glaucoma.

Zfp503/Nlz2 is Required for RPE Differentiation and Optic Fissure Closure

The paper shows that Zfp503 is essential for RPE differentiation and optic fissure closure, with loss of function leading to uveal coloboma and altered gene expression in developing mouse eyes.

Age-Related Changes in the Rhesus Macaque Eye

This study examines age-related changes in rhesus macaque eyes and compares them to human age-related eye diseases, finding similarities in intraocular pressure, retinal structure, and macular lesions.

Arap1 Loss Causes RPE Phagocytic Dysfunction and Subsequent Photoreceptor Death

This study shows that Arap1 in retinal pigment epithelium (RPE) is essential for photoreceptor survival through its role in phagocytosis, as Arap1 deficiency leads to photoreceptor degeneration.