Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism.
Mark C. Howard, Conrad A. Farrar, Christopher L. Nauser, Yusun Jeon, Anastasia Polycarpou, Dorota Smolarek, Roseanna Greenlaw, Martyn Foster, Peter Garred, Daniela A Vizitiu, Subhankar Mukhopadhyay, Steven Howard Sacks
This study shows that collectin-11 regulates osteoclastogenesis and bone maintenance through complement-dependent mechanisms, with combined deficiencies causing bone loss and spinal curvature in mice.
Proceedings of the National Academy of Sciences · Mar 3, 2026Peer-reviewedImmunology