Computational modeling and preclinical validation support targeting somatic instability for Huntington's disease treatment
Bryan P. Simpson, Paul T. Ranum, David E. Leib, Luis Tecedor, Ryan C Giovenco, Icnelia Huerta-Ocampo, Amiel R Hudley, Noah A. Smith, Christopher M. Fluta, Christopher P. Cali, Jamie D. Benoit, Jenna Carroll Soper, John Connelly, George J. Yohrling, Paiman Peter Ghoroghchian, , Beverly L. Davidson
The paper develops a computational model to predict therapeutic benefits of reducing somatic instability in Huntington's disease and validates it with preclinical experiments.
Nature Communications · Oct 28, 2026Peer-reviewedNeuroscience