Icnelia Huerta-Ocampo

The paper develops a computational model to predict therapeutic benefits of reducing somatic instability in Huntington's disease and validates it with preclinical experiments.

The paper develops humanized mouse models for SYNGAP1 and STXBP1 disorders, showing similar electrophysiological and behavioral abnormalities in mice and patients, and demonstrates the efficacy of antisense oligonucleotides in modulating SYNGAP1 expression.

The paper creates a temporal single-nucleus transcriptomic atlas of Huntington's disease mouse models to identify stage-specific transcriptional changes in corticostriatal regions.

The paper identifies an optimized AAV capsid, AAV-DB-3, that efficiently transduces deep brain and cortical structures in adult nonhuman primates at low doses.

The paper identifies an inhibitory pathway from the pedunculopontine nucleus to dopamine neurons that selectively suppresses goal-directed actions.

This study maps the whole-brain inputs to midbrain cholinergic neurons in rats, revealing distinct afferent patterns between PPN and LDT that support their differential roles in behavior.

This study identifies midbrain cholinergic neurons as a major source of acetylcholine in the striatum, showing their role in modulating striatal circuits and action control.