Author

Ryan C Giovenco

Children's Hospital of PhiladelphiaORCID 0009-0006-2690-0391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Beverly L. DavidsoniD· 2 shared Amiel R Hudley· 1 shared Bryan P. SimpsoniD· 1 shared Christopher M. Fluta· 1 shared Christopher P. CaliiD· 1 shared David E. LeibiD· 1 shared Ellie M. CarrelliD· 1 shared George J. Yohrling· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Beverly L. DavidsonORCID

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2 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedOct 28, 2026

Computational modeling and preclinical validation support targeting somatic instability for Huntington's disease treatment

Bryan P. Simpson, Paul T. Ranum, David E. Leib…·Beverly L. Davidson

The paper develops a computational model to predict therapeutic benefits of reducing somatic instability in Huntington's disease and validates it with preclinical experiments.

1 citation

humanmouse

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Molecular BiologyAnnals of NeurologyPeer-reviewedAug 29, 2025

Co-opting MBNL-dependent alternative splicing cassette exons to control gene therapy in myotonic dystrophy

Samuel Carrell, Ellie M. Carrell, Ryan C Giovenco, Beverly L. Davidson

The paper uses MBNL-dependent alternative splicing cassette exons to control gene therapy in myotonic dystrophy by tuning therapeutic protein translation.

DOI 10.1002/ana.78024

mousebulk RNA-seq

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