Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm
Melissa A. Castiglione, Yaping Jiang, Christopher Mazzeo, Sandy Lee, Juei‐Suei Chen, Kenneth Kaushansky, Wei Yin, Richard Z. Lin, Haoyi Zheng, Huichun Zhan
This study shows that JAK2V617F mutation in endothelial cells causes thrombosis, vasculopathy, and cardiomyopathy in a murine MPN model, suggesting targeting vasculature as a therapeutic strategy.
Journal of Thrombosis and Haemostasis · Sep 22, 2020Peer-reviewedMolecular Biology