Huichun Zhan

Characterization of Congestive Heart Failure Phenotype in a Murine Model of JAK2V617F-positive Myeloproliferative Neoplasm

This study characterizes heart failure in Tie2FF1 mice, showing left ventricular dilation, microvascular remodeling, and pulmonary/hepatic congestion without obstructive coronary disease.

Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular Disease

This study shows that JAK2V617F-mutant hematopoiesis causes cardiac microvascular disease, and blocking MPL signaling in endocardial endothelial cells improves cardiac function.

The Immune-Modulatory Function of Megakaryocytes in the Hematopoietic Niche of Myeloproliferative Neoplasms

This study shows that JAK2V617F mutant megakaryocytes drive immune dysregulation and HSC expansion in MPNs by reprogramming the marrow microenvironment and activating LINE-1 retrotransposons.

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm

This study shows that JAK2V617F mutation in endothelial cells causes thrombosis, vasculopathy, and cardiomyopathy in a murine MPN model, suggesting targeting vasculature as a therapeutic strategy.