Author

Melissa A. Castiglione

Albert Einstein College of MedicineORCID 0000-0002-1388-7654Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Drosophila· 1 Organism:mouse· 1

Frequent Co-Authors

Christopher Mazzeo· 1 shared Haoyi ZhengiD· 1 shared Huichun ZhaniD· 1 shared Juei‐Suei Chen· 1 shared Julie SecombeiD· 1 shared Kenneth Kaushansky· 1 shared Matanel YheskeliD· 1 shared Richard D. KellyiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Christopher Mazzeo

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2 papers

Recent·Most cited

The histone demethylase KDM5 has insulator activity in the brain

Matanel Yheskel, Melissa A. Castiglione, Richard D. Kelly, Simone Sidoli, Julie Secombe

This study shows that KDM5's non-enzymatic activities, not just demethylation, are critical for proper genomic organization and neuronal function in the brain.

bioRxiv · Dec 4, 2024 · PreprintGenetics

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm

Melissa A. Castiglione, Yaping Jiang, Christopher Mazzeo, Sandy Lee, Juei‐Suei Chen, Kenneth Kaushansky, Wei Yin, Richard Z. Lin, Haoyi Zheng, Huichun Zhan

This study shows that JAK2V617F mutation in endothelial cells causes thrombosis, vasculopathy, and cardiomyopathy in a murine MPN model, suggesting targeting vasculature as a therapeutic strategy.

Journal of Thrombosis and Haemostasis · Sep 22, 2020Peer-reviewedMolecular Biology