Author

Sandy Lee

Stony Brook UniversityORCID 0000-0002-2709-7119Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Huichun ZhaniD· 2 shared Christopher Mazzeo· 1 shared Haoyi ZhengiD· 1 shared Juei‐Suei Chen· 1 shared Kenneth Kaushansky· 1 shared Kyla Masarik· 1 shared Lei ZhengiD· 1 shared Melissa A. CastiglioneiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Huichun ZhanORCID

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2 papers

Recent·Most cited

The Immune-Modulatory Function of Megakaryocytes in the Hematopoietic Niche of Myeloproliferative Neoplasms

Sandy Lee, Xiaoxi Yang, Kyla Masarik, Tameena Ahmed, Lei Zheng, Huichun Zhan

This study shows that JAK2V617F mutant megakaryocytes drive immune dysregulation and HSC expansion in MPNs by reprogramming the marrow microenvironment and activating LINE-1 retrotransposons.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm

Melissa A. Castiglione, Yaping Jiang, Christopher Mazzeo, Sandy Lee, Juei‐Suei Chen, Kenneth Kaushansky, Wei Yin, Richard Z. Lin, Haoyi Zheng, Huichun Zhan

This study shows that JAK2V617F mutation in endothelial cells causes thrombosis, vasculopathy, and cardiomyopathy in a murine MPN model, suggesting targeting vasculature as a therapeutic strategy.

Journal of Thrombosis and Haemostasis · Sep 22, 2020Peer-reviewedMolecular Biology