A novel proviral mechanism for the ISG, Shiftless, during human coronavirus infection
Taylor M. Shue, Georgios Mourtzouchos, Dar-Yin Li, Yee Tsuey Ong, Antonis Athanasiadis, Maria Bousali, Madeleine K Sanders, Sophie N. Spector, Christopher Rivera-Bonilla, Khadija Ndoye, Kenneth C Levenson, J. Cuba, J Harris, Kelly Mieck, Shuiyun Lan, , Eleftherios Michailidis
This study reveals that the ISG Shiftless (SHFL) has both antiviral and proviral functions during coronavirus infection, enhancing susceptibility while modulating IFN signaling.
bioRxiv · Oct 31, 2026 · PreprintMicrobiology