Sophie N. Spector

This study reveals that the ISG Shiftless (SHFL) has both antiviral and proviral functions during coronavirus infection, enhancing susceptibility while modulating IFN signaling.

This study identifies the M segment of La Crosse virus as a key determinant of cell-to-cell spread, virulence, and plaque size across different viral isolates.

This study identifies eltrombopag olamine and quercetin as CCHFV entry inhibitors using a BSL-2 pseudotype screening platform validated against authentic CCHFV under BSL-4 conditions.

This paper designs an mRNA-LNP vaccine by integrating RNA, lipid, and antigen engineering to achieve 90% protection in a murine model.

This study investigates how different strains of chikungunya virus (CHIKV) and related alphavirus Mayaro virus (MAYV) infect human cardiac endothelial cells, finding that CHIKV is restricted at multiple stages while MAYV evades restriction more effectively.

This study uses genomic reassortment to identify how different segments of La Crosse virus affect infection and pathogenesis in vitro and in vivo.