Author

Jérémie Le Pen

Harvard UniversityORCID 0000-0001-7025-9526Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Eleftherios MichailidisiD· 2 shared Volker KinastiD· 2 shared Alison W. AshbrookiD· 1 shared Ana PinharandaiD· 1 shared Ansgar F. StenzeliD· 1 shared Anton J. EnrightiD· 1 shared Antonis AthanasiadisiD· 1 shared Aurélie CobatiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

Eleftherios MichailidisORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 31, 2026

A novel proviral mechanism for the ISG, Shiftless, during human coronavirus infection

Taylor M. Shue, Georgios Mourtzouchos, Dar-Yin Li…·Eleftherios Michailidis

This study reveals that the ISG Shiftless (SHFL) has both antiviral and proviral functions during coronavirus infection, enhancing susceptibility while modulating IFN signaling.

DOI 10.64898/2026.10.16.759718

humanexperimental assay

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ImmunologyPLoS BiologyPeer-reviewedSep 24, 2024

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

Jérémie Le Pen, Gabrielle Paniccia, Volker Kinast…·Charles M. Rice

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

20 citationstop 3%

humangenetic perturbation / CRISPR

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ImmunologybioRxivPreprintDec 19, 2017

Terminal uridylyltransferases target RNA viruses as part of the innate immune system in animals

Jérémie Le Pen, Hongbing Jiang, Tomás Di Domenico…·Eric A. Miska

The paper identifies terminal uridylyltransferases as a conserved antiviral mechanism in animals by uridylating viral RNA to promote degradation.

DOI 10.1101/209114

C. elegansmouse

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