Cancer-specific sialylation of insulin-like growth factor 1 receptor impairs therapeutic antibody binding and efficacy
Ayon Ahmed Hassan, Qiushi Chen, Katie Sze Wai Fung, Sally Kit Yan To, Lydia W.T. Cheung, Chenhui Zhang, Nan Liu, Chun Nan Lok, Chi‐Ming Che, Philip P.C. Ip, Xuechen Li, Alice S.T. Wong
This paper shows that cancer-specific sialylation of IGF1R reduces ganitumab binding and efficacy, and that desialylation enhances therapeutic response.
bioRxiv · Oct 17, 2025 · PreprintCancer Biology