Cancer BiologybioRxivPreprint
Cancer-specific sialylation of insulin-like growth factor 1 receptor impairs therapeutic antibody binding and efficacy
Ayon Ahmed Hassan, Qiushi Chen, Katie Sze Wai Fung…·Alice S.T. Wong
This paper shows that cancer-specific sialylation of IGF1R reduces ganitumab binding and efficacy, and that desialylation enhances therapeutic response.
DOI 10.1101/2025.10.17.682592