Alice S.T. Wong

PCRD-seq is a low-input method for profiling chromatin-associated RNAs using proximity crosslinking, showing potential for studying RNA chromatin retention and differences in cancer cell lines.

This paper shows that cancer-specific sialylation of IGF1R reduces ganitumab binding and efficacy, and that desialylation enhances therapeutic response.

This study identifies DNM1 as a master regulator of EMT in ovarian cancer, showing it sustains the mesenchymal state through N-cadherin endocytic recycling and promotes metastasis.

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

This study shows that P-cadherin-mediated mechanical forces on mesothelial cells enhance lipid production in ovarian cancer cells, promoting metastasis through lactate-driven lipogenesis.