Chunyu Deng

Mendelian randomization analysis identifies a causal effect of Streptococcus salivarius on DR mediating via the level of host fasting glucose

The paper uses Mendelian randomization to identify causal relationships between gut microbes and diabetic retinopathy, finding that Streptococcus salivarius affects DR through host fasting glucose levels.

Integration of human organoids single-cell transcriptomic profiles and human genetics repurposes critical cell type-specific drug targets for severe COVID-19

The paper integrates human organoid scRNA-seq data with GWAS and gene-drug interaction data to identify cell type-specific drug targets for severe COVID-19.

Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data

The paper introduces scPagwas, a method that integrates pathway activation transformation of scRNA-seq data with GWAS summary statistics to identify trait-relevant cell populations and pathways.

Single cell sequencing analysis uncovers genetics-influenced CD16+monocytes and memory CD8+T cells involved in severe COVID-19

The paper integrates GWAS and scRNA-seq data to identify genetics-influenced immune cell subpopulations associated with severe COVID-19, highlighting key cell types and genes involved in disease severity.

Combination of single cell sequencing data and GWAS summary statistics reveals genetically-influenced liver cell types for primary biliary cholangitis

This study integrates GWAS summary statistics with single-cell RNA sequencing data to identify genetically influenced liver cell types associated with primary biliary cholangitis.