Identification of TM4SF1 as a novel tumor-associated antigen in biliary tract cancers targetable by CAR-T cell therapy
Lorraine Nuniz, Julia H. Pham, Juliette Jacques, Corynn Kasap, Jocelin Chen, Jon Akutagawa, Josephine A. Hinneh, Chih-Hao Chang, Cindy Ament, Andrew Lewis, Arun P. Wiita, Jonathan Chou, R. Katie Kelley, Kwun Wah Wen, Vipul Kumar, Franklin W. Huang
This study identifies TM4SF1 as a tumor-associated antigen in biliary tract cancers and shows anti-TM4SF1 CAR-T cells inhibit tumor growth in vitro and in vivo.
bioRxiv · Oct 30, 2026 · PreprintCancer Biology