Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators
Pierre Francotte, Yasmin Bay, Eric Goffin, Thomas Colson, Cindy Lesenfants, Jerzy Dorosz, Saara Laulumaa, Pierre Fraikin, Pascal De Tullio, Caroline Beaufour, Iuliana Botez, Darryl S. Pickering, Karla Frydenvang, Laurence Danober, Anders S. Kristensen, , Bernard Pirotte
This paper synthesizes and evaluates thienothiadiazine dioxides as AMPA and kainate receptor modulators, identifying compounds with improved potency and selectivity.
European Journal of Medicinal Chemistry · Dec 9, 2023Peer-reviewedNeuroscience