J.S. Kastrup

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

The paper reports the crystal structure of the GluK1 ligand-binding domain complexed with kainate and the full-spanning positive allosteric modulator BPAM538, showing its unique binding mode and selectivity for GluK1.

This study develops screening assays for modulating kainate receptors GluK1-3 and provides structural insights into GluK3's ligand-binding domain.

This paper synthesizes and evaluates thienothiadiazine dioxides as AMPA and kainate receptor modulators, identifying compounds with improved potency and selectivity.

The paper presents a dimeric crystal structure of GluK2's ligand-binding domain with L-glutamate and BPAM344, revealing insights into modulation mechanisms.