Yasmin Bay

Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538

The paper reports the crystal structure of the GluK1 ligand-binding domain complexed with kainate and the full-spanning positive allosteric modulator BPAM538, showing its unique binding mode and selectivity for GluK1.

Small molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: Development of screening assays and insight into GluK3 structure

This study develops screening assays for modulating kainate receptors GluK1-3 and provides structural insights into GluK3's ligand-binding domain.

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

This paper synthesizes and evaluates thienothiadiazine dioxides as AMPA and kainate receptor modulators, identifying compounds with improved potency and selectivity.

Active-like structure of the ligand-binding domain of GluK2 with L-glutamate and the positive allosteric modulator BPAM344

The paper presents a dimeric crystal structure of GluK2's ligand-binding domain with L-glutamate and BPAM344, revealing insights into modulation mechanisms.