Polar growth factor PgfA regulates polar peptidoglycan synthesis as well as mycolate synthesis in Mycobacterium smegmatis
Karen E. Tembiwa, Alena M Truong, Cindy T Nguyen, Kuldeepkumar Ramnaresh Gupta, E. Hesper Rego, Cara C. Boutte
This paper identifies PgfA as a regulator of peptidoglycan and mycolate synthesis in Mycobacterium smegmatis, showing it can both activate and inhibit peptidoglycan metabolism depending on its binding state with TMMs.
Journal of Bacteriology · Jul 14, 2026Peer-reviewedMicrobiology