E. Hesper Rego

This paper identifies PgfA as a regulator of peptidoglycan and mycolate synthesis in Mycobacterium smegmatis, showing it can both activate and inhibit peptidoglycan metabolism depending on its binding state with TMMs.

This study identifies TapA as a regulator of cell separation and intrinsic drug resistance in Mycobacterium tuberculosis by controlling the transition between division and pole growth.

This study shows that Mycobacterium tuberculosis CTP synthase forms unique filaments that stabilize enzyme activity and resist inhibition, with mutations affecting filament formation under positive selection in clinical isolates.