BiophysicsScience AdvancesPeer-reviewed
Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1
Jesse Goyette, Citlali Solis Salas, Nicola Coker Gordon…·Omer Dushek
The paper develops a biophysical assay to study tethered signaling reactions, revealing that SHP-1 activity is significantly increased by tether binding through allosteric activation and enhanced substrate concentration.
DOI 10.1126/sciadv.1601692