Paired sequencing of IgA-bound bacteria reveals widespread associations between adaptive immunity and gut microbiome gene expression.
Logan A. Sauers, Kirsten A. L. Y. Lim, Xiaotong Zhang, Claire Morrisroe, Michał Śmiga, Matthew R. Hepworth, Katharine Z. Coyte
The paper introduces PIg-seq to study IgA-bound bacteria and finds widespread transcriptional responses, including changes in conjugation genes and prophages, linking IgA to horizontal gene transfer.
bioRxiv · Oct 5, 2026 · PreprintMicrobiology