Author

Katharine Z. Coyte

University of ManchesterORCID 0000-0002-5231-9350Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Claire Morrisroe· 1 shared Ewan Armstrong-Bond· 1 shared Kirsten A. L. Y. LimiD· 1 shared Knight CgiD· 1 shared Logan A. SauersiD· 1 shared Marek BasleriD· 1 shared Matthew R. HepworthiD· 1 shared Michael A. BrockhurstiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

Claire Morrisroe

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2 papers

Recent·Most cited

Paired sequencing of IgA-bound bacteria reveals widespread associations between adaptive immunity and gut microbiome gene expression.

Logan A. Sauers, Kirsten A. L. Y. Lim, Xiaotong Zhang, Claire Morrisroe, Michał Śmiga, Matthew R. Hepworth, Katharine Z. Coyte

The paper introduces PIg-seq to study IgA-bound bacteria and finds widespread transcriptional responses, including changes in conjugation genes and prophages, linking IgA to horizontal gene transfer.

bioRxiv · Oct 5, 2026 · PreprintMicrobiology

Multiplicity of Type 6 Secretion System toxins limits the evolution of resistance

William P. J. Smith, Ewan Armstrong-Bond, Katharine Z. Coyte, Knight Cg, Marek Basler, Michael A. Brockhurst

This study shows that multiple toxins in T6SS limit resistance evolution in bacteria, similar to combination therapies in medicine.

Proceedings of the National Academy of Sciences · Jan 9, 2025Peer-reviewedMicrobiology