Three-dimensional patient-derived models of glioblastoma retain intra-tumoral heterogeneity
Zachery Moore, Claire Storey, Daniel V. Brown, Adam Valkovic, Montana Spiteri, Jasmine F. Pignatelli, Shannon J. Oliver, Alana Fakhri, Katharine Jann Drummond, Seth W. Malinowski, Keith Lloyd Ligon, Oliver M. Sieber, James Richard Whittle, Saskia Freytag, Sarah A. Best
This paper compares patient-derived neurosphere and organoid models of glioblastoma, showing they retain intra-tumoral heterogeneity and respond to chemotherapy.
bioRxiv · Jan 8, 2025 · PreprintCancer Biology