Keith Lloyd Ligon

Heterogeneous and conserved radiation responses reveal FOXM1-dependent regulation of microcephaly genes in glioblastoma

The paper identifies FOXM1-dependent regulation of microcephaly genes in glioblastoma radiation response, showing that FOXM1 inhibition enhances radiosensitivity.

Tumor-tropic E. coli engineered as living T and NK cell engagers

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

Inertial sensing of water content in tumor spheroids

This paper measures water content in tumor spheroids using a steel tube resonator, achieving <1% precision error and detecting inter-spheroid variability and responses to kinase inhibition.

Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screens

The paper develops a CRISPR screening framework to map kinase-dependent immune evasion mechanisms in glioblastoma by integrating single-cell transcriptomics and deep generative models.

Cancers modulate p53 truncal neoantigen display to evade T cell detection

This study identifies that cancers limit p53 neoantigen display on MHC molecules, evading T cell detection through immune selection and ERAP1-mediated destruction.

O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

A diverse landscape of FGFR alterations and co-mutations defines novel therapeutic strategies in pediatric low-grade gliomas

This study identifies FGFR alterations in pediatric gliomas, their association with specific histologies, and their response to targeted therapies.

Measuring single-cell density with high throughput enables dynamic profiling of immune cell and drug response from patient samples

The paper develops a high-throughput method to measure single-cell density and applies it to study immune cell states and drug response in patient samples.

Oncogenic drivers shape the tumor microenvironment in human gliomas

This study investigates how oncogenic mutations in gliomas influence the tumor microenvironment through integrative multiomic and spatial transcriptomic analysis of glioma samples.

Three-dimensional patient-derived models of glioblastoma retain intra-tumoral heterogeneity

This paper compares patient-derived neurosphere and organoid models of glioblastoma, showing they retain intra-tumoral heterogeneity and respond to chemotherapy.

A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase

This study uses SCHEMATIC to analyze the molecular response of glioblastoma to EGFR inhibitors, identifying chemotype-specific programs and showing that combined EGFR/PI3K inhibition reduces adaptive transcription.

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.