Seth W. Malinowski

This paper measures water content in tumor spheroids using a steel tube resonator, achieving <1% precision error and detecting inter-spheroid variability and responses to kinase inhibition.

The paper develops a CRISPR screening framework to map kinase-dependent immune evasion mechanisms in glioblastoma by integrating single-cell transcriptomics and deep generative models.

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

This study identifies FGFR alterations in pediatric gliomas, their association with specific histologies, and their response to targeted therapies.

This paper compares patient-derived neurosphere and organoid models of glioblastoma, showing they retain intra-tumoral heterogeneity and respond to chemotherapy.

This study uses SCHEMATIC to analyze the molecular response of glioblastoma to EGFR inhibitors, identifying chemotype-specific programs and showing that combined EGFR/PI3K inhibition reduces adaptive transcription.