Sarah A. Best

γδ T cells modulate anti-tumor immunity in small cell lung cancer

This study identifies γδ T cell infiltration in SCLC and shows their anti-tumor activity, suggesting they could be therapeutic targets.

SpaMTP: Integrative Statistical Analysis and Visualisation of Spatial Metabolomics and Transcriptomics data.

SpaMTP integrates spatial metabolomics and transcriptomics data through a comprehensive analysis pipeline and visualization tools.

An integrative spatial multi-omic workflow for unified analysis of tumor tissue

This paper introduces a workflow for integrating spatial transcriptomics and metabolomics data to analyze glioma tissue, identifying novel biological features at the tumor's infiltrating edge.

A new genetically engineered transplant model of glioma recapitulates key phenotypes of low- and high-grade gliomas

This paper develops genetically engineered mouse cell line models (GEM-CLeMs) of glioma that recapitulate key phenotypes of low- and high-grade gliomas, offering a more accurate model of the tumor microenvironment than existing cell lines.

Three-dimensional patient-derived models of glioblastoma retain intra-tumoral heterogeneity

This paper compares patient-derived neurosphere and organoid models of glioblastoma, showing they retain intra-tumoral heterogeneity and respond to chemotherapy.

TIRE-seq: an Integrated Sample Extraction and Transcriptomics Workflow for High Throughput Perturbation Studies

TIRE-seq streamlines RNA-seq workflows by integrating mRNA purification into library preparation, improving efficiency and data quality in perturbation studies.

A Risk-reward Examination of Sample Multiplexing Reagents for Single Cell RNA-Seq

This study evaluates sample multiplexing reagents and protocols for scRNA-Seq, finding that workflow improvements and reagent choice impact data quality and cost-effectiveness.

Matrix selection for the visualization of small molecules and lipids in brain tumors using untargeted MALDI-TOF mass spectrometry imaging

The paper compares matrix, deposition technique, and polarity settings in MALDI-TOF mass spectrometry imaging for brain tumors, finding recrystallized cyano-4-hydroxycinnamic acid in positive polarity provides best performance.