Author

Clara Kielkopf

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

Dennis Liang Fei· 1 shared Harold Varmus· 1 shared Hayley Motowski· 1 shared Jovian Yu· 1 shared Rakesh Chatrikhi· 1 shared Robert K Bradley· 1 shared Sameer Prasad· 1 shared Shaojian Gao· 1 shared

Activity by Year

2016-2016 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

Dennis Liang Fei

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1 paper

Recent·Most cited

Wild-type U2AF1 antagonizes the splicing program characteristic of U2AF1-mutant tumors and is required for cell survival

Dennis Liang Fei, Hayley Motowski, Rakesh Chatrikhi, Sameer Prasad, Jovian Yu, Shaojian Gao, Clara Kielkopf, Robert K Bradley, Harold Varmus

The paper shows that wild-type U2AF1 counteracts the splicing changes caused by the S34F mutation in lung cancer and is essential for cell survival, while the mutant protein is not required for growth.

bioRxiv · Aug 24, 2016Cancer Biology