Harold Varmus

Hyperactivation of extracellular signal-regulated kinase (ERK) by RAS-mediated signaling or inhibition of dual specificity phosphatase 6 (DUSP6) is associated with toxicity in lung adenocarcinoma cells with mutations in KRAS or EGFR

The paper identifies ERK hyperactivation via RAS signaling or DUSP6 inhibition as toxic in KRAS or EGFR mutant lung adenocarcinoma cells, suggesting therapeutic strategies targeting feedback regulators.

Wild-type U2AF1 antagonizes the splicing program characteristic of U2AF1-mutant tumors and is required for cell survival

The paper shows that wild-type U2AF1 counteracts the splicing changes caused by the S34F mutation in lung cancer and is essential for cell survival, while the mutant protein is not required for growth.

The mutational landscape of EGFR-, MYC-, and Kras- driven genetically-engineered mouse models of lung adenocarcinoma

This study compares the mutational landscapes of EGFR-, MYC-, and Kras-driven lung adenocarcinoma GEMMs to human cancers, finding simpler somatic genotypes in models that are useful for engineering studies.