The splicing factor kinase, SR protein kinase 1 (SRPK1) is essential for late events in the human papillomavirus life cycle.
Arwa A. Faizo, Clare Bellward, Hegel R. Hernandez-Lopez, Andrew Stevenson, Quan Gu, Sheila V. Graham
This study shows that SRPK1 inhibition with SRPIN340 blocks HPV16 late gene expression and restores epithelial barrier and immune function by affecting splicing and gene expression.
PLoS Pathogens · Apr 9, 2025Peer-reviewedMicrobiology