Quan Gu

Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infection

This study identifies 104 cellular RNA-binding proteins within HIV-1 particles, revealing their role in viral gene expression and infectivity through interactions with HIV-1 genomic RNA.

Human Rhinovirus 16 impacts cilia structure in 3D cultured primary bronchial epithelial tissue through alternative splicing of host cilia RNAs.

This study shows HRV16 infection alters host cilia structure via alternative splicing of cilia RNAs, mediated by SRPK1 regulation.

The splicing factor kinase, SR protein kinase 1 (SRPK1) is essential for late events in the human papillomavirus life cycle.

This study shows that SRPK1 inhibition with SRPIN340 blocks HPV16 late gene expression and restores epithelial barrier and immune function by affecting splicing and gene expression.

Multi-omics analysis of virus-permissive versus hostile cellular states reveals protein networks controlling virus infection

The paper identifies protein networks associated with virus-permissive and hostile cellular states through multi-omics analysis, revealing discrepancies between mRNA and protein levels and the role of phosphorylation in infection control.

XRN1 supplies free nucleotides to feed alphavirus replication

The paper shows that XRN1-mediated RNA decay provides nucleotides for alphavirus replication by recycling monophosphate nucleotides through the salvage pathway.

A Machine Learning Framework to Identify the Correlates of Disease Severity in Acute Arbovirus Infection

This study uses machine learning to identify key viral and host processes associated with varying severity in bluetongue virus infection in sheep.

Meta-analysis of virus-induced host gene expression reveals unique signatures of immune dysregulation induced by SARS-CoV-2

This study performs a meta-analysis of transcriptomics data to identify immune dysregulation signatures in SARS-CoV-2 infection, linking gene expression patterns to patient age and disease severity.

BingleSeq: A user-friendly R package for Bulk and Single-cell RNA-Seq Data Analysis

BingleSeq provides a user-friendly R package for analyzing bulk and single-cell RNA-seq data without requiring programming expertise.

Upstream translation initiation expands the coding capacity of segmented negative-strand RNA viruses

This study shows segmented negative-strand RNA viruses use upstream translation initiation to expand their coding capacity through non-AUG initiation and host mRNA leader sequence appropriation.