The reovirus σ3 protein induces proteasomal degradation of IKKβ to modulate the host response to infection
Claudia Antonika, Durbadal Ojha, Pranav Danthi
This paper identifies reovirus σ3 as a viral protein that induces proteasomal degradation of IKKβ, reducing NF-κB activation and IFN-β expression to enhance viral replication.
bioRxiv · Jan 8, 2026 · PreprintMicrobiology