Pranav Danthi

This study develops novel oncolytic viruses derived from T1L mammalian orthoreovirus that enhance killing of therapy-resistant breast cancer stem-like cells.

This paper visualizes non-Brownian motions of reovirus particles on model membranes, revealing stepwise capsid-membrane interactions during viral entry.

This paper identifies reovirus σ3 as a viral protein that induces proteasomal degradation of IKKβ, reducing NF-κB activation and IFN-β expression to enhance viral replication.

This study identifies WDR81 as a regulator of apoptosis by repressing IKK-mediated pro-survival gene expression, revealing its role in controlling cell death during viral infection.

This study models the structure of reovirus {sigma}1 proteins and shows that flexibility in the head-body domain affects their incorporation into virions and receptor binding.

This study shows that reovirus capsids deform host membranes in a cholesterol-dependent manner, leading to membrane rupture and viral entry.

This study investigates the role of reovirus σ1 in virion stability, showing that σ1 rearrangements and a hyperstable variant contribute to heat resistance.