The major pathogen Haemophilus influenzae experiences pervasive recombination and purifying selection at local and global scales
Neil MacAlasdair, Anna Kaarina Pöntinen, Clare Louise Ling, Sudaraka Mallawaarachchi, Janjira Thaipadungpanit, François Henry Nosten, Claudia Turner, Stephen D. Bentley, Nicholas J. Croucher, Paul Turner, Jukka Corander
This study sequenced 4,475 H. influenzae isolates from Thailand and combined them with global data to show pervasive recombination and purifying selection, with MDR lineages widespread and not restricted to disease-causing subpopulations.
Nature Microbiology · Oct 31, 2025Peer-reviewedMicrobiology