François Henry Nosten

This study sequenced 4,475 H. influenzae isolates from Thailand and combined them with global data to show pervasive recombination and purifying selection, with MDR lineages widespread and not restricted to disease-causing subpopulations.

This paper develops and validates a qPCR-based assay to measure growth, resistance, and recovery of Plasmodium falciparum after artemisinin treatment, showing distinct phenotypes with independent genetic determinants.

The paper investigates the fitness consequences of selfing and outcrossing in malaria parasites using fluorescent-labelled clones and finds an outcrossing advantage linked to faster sporozoite maturation and increased recombination.

This study analyzes malaria parasite population genomics during an elimination program in Myanmar, finding genetic depauperation, localized transmission, and a dominant kelch13-R561H genotype in 2020.

This study evaluates the transmission-blocking effects of artesunate, chloroquine, and methylene blue on Plasmodium vivax gametocytes, finding that only artesunate and methylene blue significantly reduce oocyst and sporozoite development.

This study develops an open-source pipeline for identifying Anopheles mosquito species using MALDI-TOF MS with a cross-correlation approach, achieving high sensitivity and accuracy.

This paper develops and validates a MALDI-TOF MS reference database for identifying Southeast Asian Anopheles mosquito species, achieving high accuracy with molecular validation.

The paper develops a molecular barcode and online tool to identify and map imported Plasmodium vivax infections using SNP analysis and machine learning.

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

This study optimizes bulk segregant analysis for identifying drug resistance loci in Plasmodium falciparum using genetic crosses in humanized mice, confirming the kelch13 locus and demonstrating the utility of cryopreserved pools.

The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.

The paper uses bulk segregant analysis to identify genetic loci affecting malaria parasite growth in different media, finding EBA-140 as a key gene involved in media-dependent fitness.

The paper reports two new genetic crosses of Plasmodium falciparum in humanized mice, showing significant variation in marker segregation and demonstrating improved power for genetic mapping of malaria traits.

This study examines changes in genome organization during the transmission stages of Plasmodium parasites and finds that three-dimensional genome structure is linked to transcriptional activity of gene families involved in pathogenesis and immune evasion.

This paper develops a single-cell genomics protocol to reconstruct haplotypes of Plasmodium falciparum parasites and analyzes 48 cells from a malaria infection to estimate clonality and haplotype relatedness.

This paper identifies genomic variation associated with pneumococcal carriage duration using longitudinal data and genome-wide association studies.

The paper uses longitudinal genomic data from Plasmodium falciparum isolates in Thailand to identify genetic markers associated with artemisinin resistance, finding significant changes in SNPs beyond kelch13.