Chrispin Chaguza

This study examines capsule switching in Streptococcus pneumoniae using whole-genome sequences, finding that switching is limited to specific capsule-type pairs and influenced by genetic and ecological factors.

This study shows that RNA quality control through rny mutations enables antibiotic tolerance in Streptococcus pneumoniae by balancing transcriptional resilience and degradation.

MxSure estimates within-host substitution rates and transmission SNP thresholds from pairwise SNP distances, addressing challenges in microbial genome evolution analysis.

This study shows that pneumococcal growth kinetics are influenced by capsular serotype, lineage, and genetic background rather than specific loci.

This study identifies h18:0 as a toxic fatty acid produced by S. aureus that targets S. pneumoniae, and reveals genetic mechanisms allowing pneumococcus to resist its toxicity.

The paper shows that accessory capsular genes in Streptococcus pneumoniae enhance fitness, pathogenicity, and immune evasion without capsule switching.

This study analyzes the genomic data of SARS-CoV-2 Omicron BA.5 variants in the U.S. to understand their emergence patterns and transmission dynamics.

This paper develops tiled amplicon sequencing panels for whole-genome sequencing of pathogenic bacteria without culturing, enabling drug resistance classification from clinical samples.

The paper analyzes whole-genome sequences of pneumococcal isolates in Malawi to show expansion of vaccine serotype lineages with genetic changes in capsule and virulence genes post-PCV13 introduction.

This study uses deep sequencing to analyze pneumococcal genetic diversity in infants and mothers, revealing transmission patterns and treatment impacts on resistant strains.

This paper analyzes pneumococcal carriage genomic data before and after PCV13 introduction, showing reduced vaccine-type strains and limited serotype replacement.