Paul Turner

The major pathogen Haemophilus influenzae experiences pervasive recombination and purifying selection at local and global scales

This study sequenced 4,475 H. influenzae isolates from Thailand and combined them with global data to show pervasive recombination and purifying selection, with MDR lineages widespread and not restricted to disease-causing subpopulations.

The TyphiNET data visualisation dashboard: Unlocking Salmonella Typhi genomics data to support public health

The paper introduces TyphiNET, a dashboard for exploring Typhi genomics data to support public health decisions on antimicrobial resistance and vaccine implementation.

Quantifying the effects of antibiotic resistance and within-host competition on strain fitness in Streptococcus pneumoniae

This study quantifies how antibiotic resistance and within-host competition affect pneumococcal strain fitness using longitudinal carriage data.

Graph-based Nanopore Adaptive Sampling with GNASTy enables sensitive pneumococcal serotyping in complex samples

GNASTy improves pneumococcal serotyping by using a pangenome graph algorithm with Nanopore Adaptive Sampling, enhancing sensitivity for novel serotypes in complex samples.

Detection of maternal transmission of resistant Gram-negative bacteria in a Cambodian hospital setting

The paper investigates maternal transmission of ESBL-E in Cambodian infants using whole genome sequencing of mother-neonate pairs, finding evidence of bacterial transmission but not plasmid transfer.

Pneumococcal within-host diversity during colonisation, transmission and treatment

This study uses deep sequencing to analyze pneumococcal genetic diversity in infants and mothers, revealing transmission patterns and treatment impacts on resistant strains.

Genome-wide association, prediction and heritability in bacteria

This paper applies genome-wide association, prediction, and heritability analyses to bacterial data, identifying genetic factors influencing antibiotic resistance and within-host survival in Streptococcus pneumoniae.

The role of interspecies recombinations in the evolution of antibiotic resistant pneumococci

The paper reconstructs the evolutionary histories of antibiotic-resistant pneumococcal lineages PMEN3 and PMEN9, showing how interspecies recombination contributes to antibiotic resistance and serotype switching.

Metrics for Public Health Perspective Surveillance of Bacterial Antibiotic Resistance in Low- and Middle-Income Countries

The paper develops a metagenomic metric to predict antibiotic resistance in Enterobacterales infections using pooled human faecal samples from LMICs and high-income settings.

Candidatus Ornithobacterium hominis sp. nov.: insights gained from draft genomes obtained from nasopharyngeal swabs

The paper reports the discovery of a new bacterial species, Candidatus Ornithobacterium hominis, identified from nasopharyngeal swabs and describes its genomic features and colonization patterns.

Panton-Valentine leukocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial genome-wide association study

Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration

This paper identifies genomic variation associated with pneumococcal carriage duration using longitudinal data and genome-wide association studies.

Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis

This paper introduces genomeDCA, a statistical method to identify epistatic interactions in Streptococcus pneumoniae genomes, revealing networks of resistance, virulence, and core genes.

Frequent recombination of pneumococcal capsule highlights future risks of emergence of novel serotypes.

The paper analyzes genetic data to show that pneumococcal capsule recombination generates novel serotypes, highlighting risks for vaccine efficacy.

Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131

This study traces the evolutionary history of the ST131 E. coli lineage, showing its clonal expansion linked to antibiotic use and plasmid acquisition, with implications for antimicrobial resistance control.

Reagent contamination can critically impact sequence-based microbiome analyses

This study shows that reagent contamination affects sequence-based microbiome analyses, especially in low biomass samples, and provides mitigation strategies.