Differential Adaptation of Osteocyte Lacunar Morphology at Bone (Re)modeling Sites under Mechanical Loading and Pharmacological Therapies in a Mouse Model of Osteoporosis
Sara Lindenmann, Zihui Li, Claudia Weigt, Floor M. Lambers, Friederike A. Schulte, Gisela Anna Kuhn, Neashan Mathavan, Ralph Müller
The paper examines how mechanical loading and pharmacological therapies affect osteocyte lacunar morphology in a mouse osteoporosis model, showing distinct adaptations in lacunar density, volume, and sphericity.
bioRxiv · Oct 6, 2026 · PreprintBioengineering