Tau protein aggregation induces cellular senescence in the brain.
Nicolas Musi, Joseph M. Valentine, Kathryn R. Sickora, Eric Baeuerle, Cody S. Thompson, Ashley Zapata, Qiang Shen, Miranda E. Orr
This study shows that tau protein aggregation leads to cellular senescence in the brain, contributing to neurodegeneration, and that senolytic treatment can reduce pathology and improve brain function in mouse models.
Aging Cell · Aug 20, 2018Peer-reviewedNeuroscience