NeuroscienceAging CellPeer-reviewed
Tau protein aggregation induces cellular senescence in the brain.
Nicolas Musi, Joseph M. Valentine, Kathryn R. Sickora…·Miranda E. Orr
This study shows that tau protein aggregation leads to cellular senescence in the brain, contributing to neurodegeneration, and that senolytic treatment can reduce pathology and improve brain function in mouse models.