Abrupt Pericyte Loss Precedes Endothelial Activation in Cerebral Small Vessel Disease
Audrey Chagnot, Daniela Jaime García, Conor McQuaid, Justyna Cholewa-Waclaw, Karina McDade, Owen Dando, Joanna Marguerite Wardlaw, Colin G. Smith, Axel Montagne
This study identifies pericyte loss preceding endothelial activation in cerebral small vessel disease through single-vessel analysis of human brain tissue.
bioRxiv · Mar 23, 2026 · PreprintPathology