Author

Audrey Chagnot

British Heart FoundationORCID 0000-0002-9343-4777Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Axel MontagneiD· 2 shared Conor McQuaidiD· 2 shared Justyna Cholewa-WaclawiD· 2 shared Owen DandoiD· 2 shared A. GélotiD· 1 shared Alice GilbertiD· 1 shared Anne-Cécile BoulayiD· 1 shared Armelle RancillaciD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Axel MontagneORCID

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Author profile →

3 papers

Recent·Most cited

Pericyte Loss Reprogrammes Capillary Endothelium and Drives White Matter Injury in Small Vessel Disease

Dorota Stefancova, Audrey Chagnot, Michael D.E. Sewell, Nela Fialova, Conor McQuaid, Joseph O. Uweru, Solvig Becker, Marina Romero-Bernal, William Mungall, Vicky Walczak-Gillies, Tracy D. Farr, Ross J. Lennen, Maurits A. Jansen, Owen Dando, Justyna Cholewa-Waclaw, Axel Montagne

bioRxiv · May 13, 2026 · PreprintNeuroscience

Abrupt Pericyte Loss Precedes Endothelial Activation in Cerebral Small Vessel Disease

Audrey Chagnot, Daniela Jaime García, Conor McQuaid, Justyna Cholewa-Waclaw, Karina McDade, Owen Dando, Joanna Marguerite Wardlaw, Colin G. Smith, Axel Montagne

This study identifies pericyte loss preceding endothelial activation in cerebral small vessel disease through single-vessel analysis of human brain tissue.

bioRxiv · Mar 23, 2026 · PreprintPathology

Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit

Alice Gilbert, Xabier Elorza‐Vidal, Armelle Rancillac, Audrey Chagnot, Mervé Yetim, Vincent Hingot, Thomas Deffieux, Anne-Cécile Boulay, Rodrigo Alvear‐Perez, Salvatore Cisternino, Sabrina Martín, Sonia Taïb, A. Gélot, Virginie Mignon, Maryline Favier, , Martine Cohen‐Salmon

This study shows that MLC1 is essential for postnatal development of the gliovascular unit, leading to vascular and fluid clearance defects in a mouse model of megalencephalic leukoencephalopathy.

eLife · Nov 1, 2021Peer-reviewedNeuroscience