Joanna Marguerite Wardlaw

The paper shows that general cognitive function is supported by a widespread white matter network across multiple brain regions and connectivity measures.

This study examines the association between APOE4 genotype, BBB permeability, and infarct distribution in patients with mild ischemic stroke, finding a posterior-predominant infarct distribution in APOE4 carriers despite similar BBB metrics.

This study identifies pericyte loss preceding endothelial activation in cerebral small vessel disease through single-vessel analysis of human brain tissue.

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

This paper predicts one-year WMH evolution post-stroke using MRI and stroke lesion data with a probabilistic deep learning model, achieving improved accuracy through joint segmentation and a new loss function.

The paper identifies brain regions most related to general cognitive function and links them to neurobiological properties using meta-analysis and multimodal cortical maps.

The paper develops epigenetic scores for GDF15 and NT-proBNP levels, showing associations with disease risks and brain health traits in two cohorts.

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

This paper develops an epigenetic score to objectively measure alcohol consumption using blood-based DNA methylation and validates it across multiple cohorts, finding associations with brain health metrics.

The paper identifies DNA methylation and proteomic markers associated with brain health through integrated methylome and phenome analyses.

This study identifies DNA methylation predictors of cognitive function using blood samples, showing they explain variance in cognitive ability and associate with biological markers.

This study identifies intrinsic endothelial dysfunction as a cause of cerebral small vessel disease in a normotensive rat model, independent of hypertension.

The paper describes an MRI dataset and processing pipeline for the EPAD study, identifying quality control features and image-derived phenotypes related to aging and dementia.

This study identifies three dimensions of cortical ageing in the human brain and links the most general dimension to cognitive decline across multiple domains in older adults.

The paper examines the association between birth weight and brain structure in older age, finding positive links with brain volumes but not with age-related structural changes.

This study identifies lipid biomarkers associated with brain structure but not cognitive ability in older adults using metabolomic data from the LBC1936 cohort.

This study examines age-related changes in PSMD across the adult lifespan using multi-cohort diffusion tensor imaging data, finding PSMD increases consistently while other metrics show different age patterns.

This paper introduces DEP models to predict white matter hyperintensity evolution in brain MRI, showing that semi-supervised models with Gaussian noise inputs perform best.

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

This study examines the genomic architecture of neuroanatomical diversity using SNP data and MRI, finding polygenic influences and environmental factors affecting brain asymmetry.

The paper quantifies perivascular spaces (PVS) in brain MRI and links them to retinal microvascular parameters in older adults, finding associations with arteriolar narrowing and reduced branching complexity.

The paper examines how aging affects brain network integrity and its association with cognitive function using MRI data from two cohorts.

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

The paper introduces LOTS-IM, an unsupervised method for detecting white matter hyperintensities and MS lesions in MRI, showing better performance than existing methods.

The paper quantifies microstructural changes in normal-appearing white matter near white matter hyperintensities in older adults, showing spatial gradients of damage linked to WMH burden.

This study identifies neurology-related proteins in plasma associated with cognitive ability and brain volume in older adults, with partial mediation by brain volume.

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.