Identification of a novel GREMLIN1 uptake pathway in epithelial cells that requires BMP binding
Zhichun Gao, Yuhan Gao, Louise R. Dutton, Melibea Berzosa, Grace Todd, Gregory R. Gipson, Connor Brown, Emma M. Kerr, Carole A. Daly, Bianca Plouffe, Philip D. Dunne, Dessislava Malinova, Derek P. Brazil
The paper identifies a BMP-dependent endocytosis pathway for GREM1 in epithelial cells, showing BMP binding is required for GREM1 uptake and antagonism of BMP signaling.
Journal of Biological Chemistry · Sep 30, 2025Peer-reviewedCell Biology