Author

Louise R. Dutton

University of GlasgowORCID 0000-0002-9336-7826Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

AJ Chalmers· 1 shared Bianca PlouffeiD· 1 shared Carole A. Daly· 1 shared Connor Brown· 1 shared Crispin J. MilleriD· 1 shared Derek P. BraziliD· 1 shared Dessislava MalinovaiD· 1 shared Emma M. KerriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

AJ Chalmers

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Identification of a novel GREMLIN1 uptake pathway in epithelial cells that requires BMP binding

Zhichun Gao, Yuhan Gao, Louise R. Dutton, Melibea Berzosa, Grace Todd, Gregory R. Gipson, Connor Brown, Emma M. Kerr, Carole A. Daly, Bianca Plouffe, Philip D. Dunne, Dessislava Malinova, Derek P. Brazil

The paper identifies a BMP-dependent endocytosis pathway for GREM1 in epithelial cells, showing BMP binding is required for GREM1 uptake and antagonism of BMP signaling.

Journal of Biological Chemistry · Sep 30, 2025Peer-reviewedCell Biology

Radiotherapy drives lung metastasis in PDAC via a RhoGTPasesignaling shift towards MRCK-dependency

Kathy McLay, Mathias Tesson, Louise R. Dutton, Yihong Sun, Josette M Misquitta, Katrina H. Stevenson, Ryan Corbyn, Sérgio Lilla, Lynn McGarry, N Maka, R Shaw, Crispin J. Miller, LM Carlin, AJ Chalmers, Michael F. Olson, , JL Birch

This study shows that radiotherapy promotes lung metastasis in PDAC by increasing MRCK activity, which can be inhibited by BDP9066.

bioRxiv · Sep 9, 2025 · PreprintCancer Biology