Intrathecal infusion of hypertonic fluid enables CSF Flow Enhancement (CFE) to facilitate nanoparticle delivery to the brain and spinal cord
Oluwatobi Helen Babayemi, Kha Uyen Dam, Chung-Fan Kuo, Olivia Mihalek, Elena A. Andreyko, Constance Jennifer Mietus, Shaokuan Zheng, Hong Wei Yang, Rachael W. Sirianni
This study demonstrates that intrathecal infusion of hypertonic fluid enhances cerebrospinal fluid flow, significantly improving nanoparticle delivery to the central nervous system.
bioRxiv · Jul 1, 2026 · PreprintBioengineering